Nexium (esomeprazole magnesium) - drug information from medilexicon Company: AstraZeneca
Approval Status: Approved February 2001
Treatment for: Duodenal ulcer disease, erosive esophagitis, and gastroesophageal reflux disease
Areas: Gastrointestinal
General Information Clinical Results Negative effects Mechanism of Action Further information
General Information
Nexium has been licensed by the FDA for the relief of heartburn
and also other symptoms connected with gastroesophageal reflux disease
(GERD) and also for the healing of erosive esophagitis, a potentially
serious condition connected with GERD. The FDA also approved
Nexium for repair off healing of erosive esophagitis and, in
in conjunction with amoxicillin and clarithromycin, with the
eradication of Helicobacter pylori infection in patients
with duodenal ulcer disease.
Nexium is derived from Prilosec (omeprazole). Prilosec contains
a racemic combination of the D- and L- forms (isomers) of omeprazole. Nexium contains just one with the isomers. Both Prilosec and Nexium
are known as proton pump inhibitors.
As many as 25 million adults experience heartburn using a daily
basis buy nasonex online without prescription. Although heartburn is regarded as the common sign of GERD, the
condition can be often marked by other symptoms - say for example a sour
style of the mouth or difficulty swallowing - relevant to the
storing of harsh gastric acid into your esophagus. Once this acid
reflux damages the lining of the esophagus, it may well create a
potentially more dangerous condition called erosive esophagitis that
can lead to narrowing or ulceration with the esophagus.
Clinical Results
Four multicenter, double-blind, randomized trials evaluated the
healing rates of Nexium 40 mg, Nexium 20 mg, and omeprazole 20 mg
in subjects with endoscopically diagnosed erosive esophagitis. Healing rates were evaluated at week four and eight. At week eight,
healing rates were higher with Nexium treatment as compared to
omeprazole in all of the four studies.
Two multicenter, randomized, double-blind, placebo-controlled
4-arm trials evaluated the long-term upkeep of healing of
erosive esophagitis. The trials included subjects with
endoscopically confirmed, healed erosive esophagitis, and so they
evaluated Nexium 40 mg, 20 mg and 10 mg once-daily over a few months
of treatment. Subjects remained in remission significantly longer
along with the volume of recurrences of erosive esophagitis was
a reduced amount of in subjects addressed with Nexium in comparison with
placebo.
Nexium's effectiveness within the resolution of GERD symptoms
was evaluated into two multicenter, randomized, double-blind,
placebo-controlled trials. These trials were conducted in the total
of 717 subjects, and they compared four weeks of treatment with
Nexium 20 mg or 40 mg once daily versus placebo. The percentage of
subjects have been symptom-free of heartburn was significantly
higher from the Nexium groups as compared to placebo by any means follow-up
visits (weeks 1, 2 and 4).
In three European symptomatic GERD trials, no significant
treatment related differences were observed between Nexium 20 mg
and 40 mg and omeprazole 20 mg.
Nexium in combination with amoxicillan and clarithromycin was
tested by 50 percent multicenter, randomized, double-blind trials to the
eradication of Helicobacter pylori (H. pylori) in subjects with
duodenal ulcer disease. H. pylori eradication rates at a month
post-therapy were significantly higher within the Nexium plus
amoxicillin and clarithromycin group compared with a Nexium plus
clarithromycin or Nexium alone group.
Uncomfortable side effects
Side effects reported with Nexium use include (but aren't
limited to) the next:
- Headache
- Diarrhea
- Abdominal pain
Safety and effectiveness have not yet been established in
pediatric patients.
Please talk to your physician for even more home elevators side
effects or even discuss the average person appropriateness of Nexium
treatment.
Mechanism of Action
Esomeprazole is usually a proton pump inhibitor that suppresses gastric
acid secretion by specific inhibition of H+/K+-ATPase within the
gastric parietal cell. By acting specifically around the proton pump,
esomeprazole blocks the final help acid production, thus
reducing gastric acidity. This effect is dose-related up to and including daily
dose of 20 to 40 mg and contributes to inhibition of gastric acid
secretion. buy retin-a online without prescription (Nexium Prescribing Information)
More information
Nexium is made in a delayed-release capsule formulation,
with dosages of 20 mg or 40 mg.
For additional information on Nexium, please visit
AstraZeneca.
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